The audible system in Madden 25 has been completely revamped from previous versions of the game. Before most of you start crying over this change, it should be noted that the new audible system is about 500 times better than what we've had in previous Madden games.
To put it simply, you can only audible to formations which utilizes the same personnel package that you currently have on the field at the time. To better demonstrate what this means, an example is provided below.
Say you come out in a formation with 1 tight end, 3 wide receivers, and 1 running back. When you go to audible at that point, you will only be allowed to audible to a play that uses that same personnel group. So you can audible from shotgun normal (a formation that uses 1 tight end, 3 wide receivers, and 1 running back) to singleback ace y-trips (another formation that uses 1 tight end, 3 wide receivers, and 1 running back). You will not be able to audible to something like I-form tight because that uses a different personnel group (2 tight ends, 2 running backs, and 1 wide receiver).
In previous games, you could audible to any formation you choose even if that formation called for 2 running backs, 2 tight ends, and 1 wide receiver. This created all sorts of mismatches with gamers able to get wide receivers lined up as running backs or wide receivers lined up as tight ends.